S.E.M.I.: Side Effects May Include...

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Released 23 January 2026 for PC (Microsoft Windows) by Two Horn Unicorn. Rated E10+ by ESRB, 12 by PEGI. 4-player online co-op.

S.E.M.I.: Side Effects May Include... screenshots

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