Colony on the Run

"Colony on the Run is a 2D roguelite action game set inside the human body."

· December 10, 2026· Main Game

Colony on the Run is a 2D roguelite action game set inside the human body. Starting as a single bacterium, players must multiply their colony, evade immune cells, and evolve new abilities to survive. Explore different organs, each featuring unique environmental hazards and challenges. Survive attacks from white blood cells and powerful bosses while preparing for a devastating antibiotic wave at the end of each stage. But survival comes with a twist: if the human host dies, it's game over for the bacteria too. Developed by a practicing respiratory physician, Colony on the Run combines fast-paced survival action with a unique microscopic setting.

Story

Starting as a single bacterium inside the human body, a tiny colony embarks on a journey in search of a safe place to call home.

Along the way, the colony must survive relentless attacks from the immune system, overcome the dangers of different organs, and endure powerful antibiotics.

Will the bacteria find a place where they can finally live in peace?